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<Journal>

<JournalID>18</JournalID>

<PubDate_Fa>Payiz 1388</PubDate_Fa>

<PubDate_En>Fall 2009</PubDate_En>

<Volume>10</Volume>

<Number>3</Number>

<Abstract>

<AbstractID>174</AbstractID>

<Title>CORRELATION BETWEEN BLOOD LEVELS OF CRP,

TNF-a (AS INFLAMMATORY FACTORS), AND IL-10

(AS ANTI-INFLAMMATORY FACTOR) AND

CORONARY ARTERY DISEASE</Title>

<Author>H. A. BASSIRI MD1, NOZAR GIVTAJ PHD 2, NADER GIVTAJ MD 3 AND F. NOOHI MD</Author>

<Background>The results of a great amount of research done the world over in recent years have

indicated that atherosclerosis is an inflammatory disease. Most of these investigations were

conducted on the correlation between inflammatory factors such as CRP, IL-2, and IL-1 and

atherosclerosis. In this study, we evaluated inflammatory factors such as CRP and TNF-a as well

as anti-inflammatory factor IL-10 and analyzed the correlation between the balance of these

factors with atherosclerosis.</Background>

<Method>In total, 135 patients between the ages of 45 and 70 years who were admitted for coronary

angiography were selected. All of the selected patients met the inclusion criteria for the research.

After recording personal information, medical history, and any previous treatment in the

questionnaire, blood samples were collected and levels of CRP (high-sensitive quantitative test),

TNF-a, and IL-10 were measured in all the samples. We entered the acquired results, the routine

blood examination, and the angiography results in the patients  charts and analyzed the results

using statistical methods.</Method>

<Result>The angiography results in the 135 patients were as follows: 19 (14.1%) cases had normal

coronary arteries, 6 (4.4%) had minimal CAD, 43 (31.8%) had single-vessel disease, 29 (21.5%)

two-vessel, and 38 (28.1%) had three-vessel disease. In the laboratory tests, the mean CRP level

in patients with normal coronary arteries was 6±4 mg/l; however in patients with CAD it was

17±9 mg/l. Also, the mean IL-10 level in cases with normal coronary arteries was 4.4 pgr/mL,

while in patients with CAD it was 2.6 pgr/mL; and serum level of TNF-a in patients with CAD

was 6.3±3.8 pgr/mL, whereas in cases with normal coronary arteries, the average serum level of

TNF-a was 4.5 ± 2.2 pgr/mL.</Result>

<Conclusion>The obtained results in this research showed a direct correlation between the blood levels

of CRP and TNF-a with the existence and intensity of coronary artery disease. In addition, we

found a reverse significant correlation between blood levels of IL-10 and existence of coronary

artery disease. Although we found a correlation between reduced levels of IL-10 and intensity of

coronary artery disease, it was not statistically significant. Furthermore, in patients with elevated

blood levels of inflammatory and anti-inflammatory factors, the intensity of the coronary artery

disease was far less than that in patients with high levels of inflammatory factors and reduced

levels of anti-inflammatory factors. Therefore, we concluded that high levels of CRP and TNF-a

and low levels of IL-10 had a significant correlation with the intensity of coronary artery disease

and also the balance between these factors had a significant correlation with the intensity of the

coronary artery disease (Iranian Heart Journal 2009; 10 (3):6-11).</Conclusion>

<Keywords>coronary artery disease, C-reactive protein, tumor necrosis factor-a, interleukin-10 (IL-10),

inflammation</Keywords>

</Abstract>

<Abstract>

<AbstractID>175</AbstractID>

<Title>The Effects of Ultrafiltration on Postoperative Respiratory

Status in Adults Undergoing Coronary Artery Bypass

Grafting</Title>

<Author>Abdollah Panahipour, MD1 and Ali Dabbagh MD2</Author>

<Introduction>Systemic inflammatory response syndrome (SIRS) remains one of the major causes of cardiopulmonary

bypass-associated organ injury during adult cardiac surgery. This study was designed and performed to assess the

short-term effects of this technique on postoperative lung status in such patients.</Introduction>

<Method>In a double-blind, randomized clinical trial, 90 patients scheduled for elective CABG were selected and

randomly assigned into 2 groups; the first group had ultrafiltration in their cardiopulmonary bypass circuit.</Method>

<Result>The case group patients were extubated sooner compared to the control group. The postoperative oxygenation

status in the case group was better than the control group.</Result>

<Conclusion>The results of this study demonstrated that ultrafiltration could improve the postoperative respiratory

status of those adults undergoing coronary artery bypass grafting (Iranian Heart Journal 2009; 10 (3):12-16).</Conclusion>

<Keywords>ultrafiltration, coronary artery bypass graft surgery, respiratory status</Keywords>

</Abstract>

<Abstract>

<AbstractID>176</AbstractID>

<Title>Comparative Study of Pulmonary Function Tests before

and After Successful Percutaneous Transvenous Mitral

Commissurotomy</Title>

<Author>Hasan Allah Sadeghi MD,* N. Paziraee MD**, M. M. Zahmatkesh MD***,

R. Miri MD, H.A. Bassiri MD, A. Sadeghpour MD, N. Samiee MD and F. Noohi MD</Author>

<Background>Mitral stenosis (MS) causes elevation of left atrial and pulmonary venous pressures.

Persistent elevation of pulmonary venous pressure causes anatomical and physiological

changes in lung vasculature and tissue, and change in lung volumes thereafter. Studies showed improvement of lung function with improvement of mitral stenosis and decrease in left atrial pressure and pulmonary congestion. This study was performed to evaluate lung volumes before and after percutaneous transvenous mitral commissurotomy (PTMC), including FEV1, FVC, SVC, and their percent and FEF of 25, 50, 75, 25-75 percent and PEFR before and within 48 h after PTMC, and to evaluate correlation of each with valve area.</Background>

<Method>26 from 51 patients with inclusion criteria stayed in the study with non-random

consequential selection and the others were excluded. All of the patients had moderate to

severe MS, good mitral valve morphology, echo score below 11, and absence of clot in the left

atrium. Spirometery was done in all of the patients before and after PTMC and FEV1, FVC, SVC, FEF25%, FEF50%, FEF75%, FEF25-75% FEV1/FVC, and PEFR were measured.</Method>

<Result>There were 26 patients (12 female, 14 male) with a mean age of 38.38 years old, mitral

valve area was 0.88 cm2 before and 1.46 cm2 after PTMC (mean 0.58 cm2 increase (p&lt;.000).

Mean value of lung volumes and flow changes were: SVC change= 100 ml (p&lt;0.1), FVC=230

ml (p&lt;0.005), FEV1=250 ml (p&lt;0.003), FEF50%=0.85 (p&lt;0.004), FEF25% =0.98 (p&lt;0.003),

and FEF25-75%=0.71 (p&lt;0.01). Values for SVC, PEFR, and FEF75% were not significant.</Result>

<Conclusion>Mean value of FEV1, FVC, FEF50%, FEF25% and FEF25-75% increased significantly,

but SVC, FEF 75% and PEFR had no significant improvement. This may suggest improvement

of small airway function due to a decrease in lung congestion (Iranian Heart Journal 2009; 10 (3):17-21).</Conclusion>

<Keywords>percutaneous transvenous mitral commissurotomy, pulmonary function tests, mitral stenosis, spirometery</Keywords>

</Abstract>

<Abstract>

<AbstractID>177</AbstractID>

<Title>The Role of Human Platelet Antigen 1 Polymorphism in

Development of Coronary Artery Stenosis in Iranian

Population</Title>

<Author>B. Naghshtabrizi 1, R. Kiani 2, H. R. Sanati 3, F. Emami 4, M. Hajiloo 4

and P. Meschi5</Author>

<Background>Aggregation is the final step in activation of platelets and is mediated by presentation

of GPIIb/IIIa receptors on the platelet membrane that binds to fibrinogen and von

Willebrand s factor. There are common mutations in GPIII structure that can change the

behavior of the molecule and may change the pattern of interaction between platelets and

injured endothelium, thus they can have prognostic impact in coronary artery disease (CAD)

and acute coronary syndrome. In some large trials, persons homozygous for the PlA2 allele

had a greater chance of coronary stenosis and myocardial infarction (MI) than heterozygotes

or non-carriers, but other studies did not confirm this association. This is the first study of PlA

polymorphism in Iran and is aimed to find a possible association of this mutation and CAD in the Iranian population.</Background>

<Method>In this case-control study, we chose 200 patients who underwent diagnostic coronary

angiography between 2005 and 2006 in Hamedan, Iran. In these patients HPla genotype determination was done using PCR method.</Method>

<Result>We found no significant association of coronary artery stenosis and PlA2A2 or PlA1A2

genotypes in our patients, p value&gt;0.05. However, there was a significant association between

possession of PlA2 allele and occurrence of CAD in patients more than 50 years of age, p value 0.045.</Result>

<Conclusion>Variations in PlA phenotype do not seem to have an association with ischemic heart

disease, but the PlA2 allele may have a role in the development of atherosclerosis and MI in persons more than 50 years of age (Iranian Heart Journal 2009; 10 (3):22-26).</Conclusion>

<Keywords>coronary artery disease, human platelet antigens, polymorphism</Keywords>

</Abstract>

<Abstract>

<AbstractID>178</AbstractID>

<Title>Efficacy and Safety of Tenecteplase (Metalyse) in Iraqi

Patients with Acute ST-Elevation Myocardial Infarction</Title>

<Author>*Abbas Al-Sharifi MD, FACC, FRCP, FESC, FICMS, Hussen ALazawi MD,

CABM and Ali Swadi MB,CHB, FICMS</Author>

<Background>Thombolytic therapy using tissue plasminogen activator has revolutionized the treatment of acute

myocardial infarction. Tenecteplase was developed as a bioengineered variant of tissue-type plasminogen

activator with specific, desirable properties. The aim of this study is to assess the efficacy and safety of tenecteplase in patients with AMI.</Background>

<Method>50 patients with acute STEMI were enrolled in this study; those patients had presented to the hospital within

12 hours of the onset of their chest pain and fulfilled the criteria of starting thrombolytic therapy. They had been

randomly selected consecutive patients from those attending the coronary care unit of Al-Yarmouk Teaching

Hospital, Baghdad during the period from October 2005 to August 2006. Tenectaplase infusion over ten seconds

was given according to body weight. ST-segment resolution was defined as reduction in the ST-elevation of 50% or more at 90 minutes.</Method>

<Result>40 patients (80% of the sample) were male. The range of patients  age was 28-80 years, with a mean of 54.94 ±

10.83 years and a median of 53 years old. ST- segment resolution had been observed in 27 patients (54% of the

sample). The mean age of those with successful thrombolysis was 52.78 ± 10.8 years old, and 59.13 ± 10.3 years

old for those who failed to respond to the thrombolytic therapy with tenecteplase. Statistical analysis revealed a

highly significant effect of age on the frequency of ST-segment resolution (calculated t= 24.78, p-value

&lt;0.0001). The mean time to perfusion was 2.4 ± 2.37 hours and 4.76 ± 3.25 hours for those with successful

thrombolysis and those who failed to respond, respectively. Eight out of 12 patients diagnosed with inferior

STEMI had successful reperfusion. No one with double wall infarction had successful reperfusion. Two patients

with diabetes (15.4%) and only 1 patient with hyperlipidemia (11.1%) had successful thrombolysis. None of

those with 3 or more risk factors (7 patients) had successful reperfusion. The study showed that female patients

had a higher chance of failure of thrombolysis (Iranian Heart Journal 2009; 10 (3):27-35).</Result>

<Keywords>acute myocardial infarction, thrombolytic therapy, tenectaplase</Keywords>

</Abstract>

<Abstract>

<AbstractID>179</AbstractID>

<Title>Detection of Atherosclerotic Plaque Composition Using

Intravascular Images</Title>

<Author>A. Taki MSc1, M. Maadani MD2, S. Setarehdan PhD1, A. Roodaki M.SC1 ,

H. R. Sanati MD2 and N. Navab PhD3</Author>

<CaseReport>Acute coronary syndromes (ACS) and sudden cardiac death are the main causes of morbidity and

mortality in the world.1 ACS are often the first manifestation of coronary artery disease, and the

rupture of a coronary plaque is the main cause of ACS. Histopathological studies have revealed that

the majority of thrombi result from plaque rupture.

Grayscale intravascular ultrasonography (IVUS), a tomographic imaging tool, can visualize

coronary atherosclerosis in vivo, elucidating plaque area, plaque distribution, lesion length, and

coronary remodeling. IVUS has demonstrated the discrepancies between the extent of

atherosclerosis seen by coronary angiography and the actual extent of atherosclerotic disease.2

Quantitative assessment of plaque composition has, however, not been possible with grayscale

IVUS analysis, until now3 (Iranian Heart Journal 2009; 10 (3):36-43).</CaseReport>

<Keywords>atherosclerosis, plaque, intravascular ultrasound</Keywords>

</Abstract>

<Abstract>

<AbstractID>180</AbstractID>

<Title>Suction Tip Migration to Internal Iliac Vein during Cardiac

Surgery</Title>

<Author>Masoumali Masoumi MD and Feridoun Sabzi MD*</Author>

<CaseReport>During the cannulation of the inferior vena cava in a 29-year-old patient undergoing mitral and

aortic valve replacement, the pump suction tip was inadvertently lost in the right atrium. After

starting CPB and cardioplegic arrest of the heart, the right atrium and ventricle were searched

for the foreign body, but it became evident by reontgenography that the foreign body had

migrated to the pelvic veins. At the end of the operation, extraction with a Fogarty catheter was

attempted but was not successful and the foreign body was extracted via laparatomy (Iranian

Heart Journal 2009; 10 (3):44-46).</CaseReport>

<Keywords>foreign body migration, iliac vein, heart surgery</Keywords>

</Abstract>

<Abstract>

<AbstractID>181</AbstractID>

<Title>Atrial Septal Aneurysm Concomitant with Severe Mitral

Stenosis</Title>

<Author>Saeed Hosseini MD, Mehdy Hadadzadeh MD, and Alireza Alizadeh Ghavidel MD</Author>

<CaseReport>An atrial septal aneurysm is an uncommon abnormality and may be the origin of thromboembolic

events. We herein present an unusual case of this septal abnormality with mitral stenosis and history

of thromboembolic cerebrovascular accident (Iranian Heart Journal 2009; 10 (3):47-49).</CaseReport>

</Abstract>

<Abstract>

<AbstractID>182</AbstractID>

<Title>Right Ventricular Infarction and Refractory Hypoxemia

Following Coronary Artery Bypass Graft Surgery</Title>

<Author>G. Soltani MD1 and M. Abbasi MD2</Author>

<CaseReport>Right ventricular (RV) infarction occurs in 19% to 51% of patients with left ventricular inferior wall acute myocardial

infarction.1,2 The importance of RV infarction and its unique hemodynamic consequences were not well understood

until the early 1970s. Among these consequences are hemodynamic disturbances, which may be mistaken for left

ventricular dysfunction, pericardial tamponade, and pulmonary embolism. Another serious consequence associated with

RV infarction is sudden right-to-left shunting through a previously unsuspected atrial septal defect (ASD) or patent

foramen ovale (PFO). We herein describe a patient in whom postoperative RV infarction was associated with refractory

hypoxemia through a PFO (Iranian Heart Journal 2009; 10 (3):50-52).</CaseReport>

<Keywords>coronary artery bypass graft, myocardial infarction, right ventricle, hypoxemia</Keywords>

</Abstract>

<Abstract>

<AbstractID>183</AbstractID>

<Title>Approach to the Patient with Combined Coarctation of

Aorta and Wolf-Parkinson-White Syndrome</Title>

<Author>Hossein Ali Bassri MD1, Seifollah Abdi MD1, Hamid Reza Sanati MD1, Reza Kiani

MD1, Zahra Ojaghi-Haghighi MD2, Fereidoun Noohi MD, FACC2 and

Majid Haghjoo MD, FESC3</Author>

<CaseReport>At the present time the treatment of choice for postductal coarctation of aorta is percutaneous angioplasty and stenting.

One crucial step for successful stenting of coarctation is accurate positioning of the stent across the lesion, which is

difficult due to high pressure blood flow at the site of the coarct. To solve this problem, rapid pacing has been used to

decrease cardiac output and blood pressure for a few seconds and prevent excessive motion of the stent during

deployment. However, if coarctation is combined with pre-excitation syndrome, rapid atrial/ventricular pacing could

cause life-threatening tachyarrhythmias. In this paper, we report a 28-year-old woman with combined coarctation of

aorta and Wolf-Parkinson-White syndrome who underwent radio frequency catheter ablation of the accessory pathway

and then stenting angioplasty of the coarctation was performed without any complication (Iranian Heart Journal

2009; 10 (3):53-55).</CaseReport>

<Keywords>coarctation of aorta, Wolf-Parkinson-White syndrome, angioplasty</Keywords>

</Abstract>

</Journal>